The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma

Medulloblastoma, the most common malignant childhood brain tumor, exhibits distinct molecular subtypes and cellular origins. Genetic alterations driving medulloblastoma initiation and progression remain poorly understood. Herein, we identify GNAS, encoding the G-protein Gsα, as a potent tumor suppre...

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Publicado en:Nat Med
Main Authors: He, Xuelian, Zhang, Liguo, Chen, Ying, Remke, Marc, Shih, David, Lu, Fanghui, Wang, Haibo, Deng, Yaqi, Yu, Yang, Xia, Yong, Wu, Xiaochong, Ramaswamy, Vijay, Hu, Tom, Wang, Fan, Zhou, Wenhao, Burns, Dennis K., Kim, Se Hoon, Kool, Marcel, Pfister, Stefan M., Weinstein, Lee S., Pomeroy, Scott L., Gilbertson, Richard J., Rubin, Joshua B., Hou, Yiping, Wechsler-Reya, Robert, Taylor, Michael D., Lu, Q. Richard
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334261/
https://ncbi.nlm.nih.gov/pubmed/25150496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3666
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