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Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2.

Lesatropane, a synthesized chiral tropane (3S, 6S-isomer of satropane), is a novel muscarinic agonist, and is being under preclinical development in China for the treatment of primary glaucoma. The reports concerning that activation of muscarinic acetylcholine receptors (mAChRs) could protect cells...

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Detalhes bibliográficos
Publicado no:Bosn J Basic Med Sci
Main Authors: Ma, Ke, Yang, Zhi-Hui, Yang, Li-Min, Chen, Hong-Zhuan, Lu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333984/
https://ncbi.nlm.nih.gov/pubmed/23988164
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