xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseases

Expression of xCT, a component of the x(c)(–) amino-acid transporter, is essential for the uptake of cystine required for intracellular glutathione (GSH) synthesis and maintenance of the intracellular redox balance. Therefore, xCT plays an important role not only in the survival of somatic and immun...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Dai, Lu, Noverr, Mairi C., Parsons, Chris, Kaleeba, Johnan A. R., Qin, Zhiqiang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Public Health
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333839/
https://ncbi.nlm.nih.gov/pubmed/25745420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00120
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