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A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation
BACKGROUND: Type 1 long QT syndrome (LQT1) is caused by loss-of-function mutations in the KCNQ1-encoded Kv7.1 channel that conducts the slowly activating component of the delayed rectifier K(+) current (I(Ks)). Clinically, the diagnosis of LQT1 is complicated by variable phenotypic expressivity, whe...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Heart Rhythm |
|---|---|
| Prif Awduron: | , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2013
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4333640/ https://ncbi.nlm.nih.gov/pubmed/24269949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2013.11.021 |
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