A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms

p63 is a crucial regulator of epidermal development, but its transcriptional control has remained elusive. Here, we report the identification of a long-range enhancer (p63LRE) that is composed of two evolutionary conserved modules (C38 and C40), acting in concert to control tissue- and layer-specifi...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Antonini, Dario, Sirico, Anna, Aberdam, Edith, Ambrosio, Raffaele, Campanile, Carmen, Fagoonee, Sharmila, Altruda, Fiorella, Aberdam, Daniel, Brissette, Janice L., Missero, Caterina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333422/
https://ncbi.nlm.nih.gov/pubmed/25567987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1396
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