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A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function

p53 functions as a tumor suppressor by transcriptionally regulating the expression of genes involved in controlling cell proliferation or apoptosis. p53 and its isoform Δ133p53/Δ113p53 form a negative regulation loop in that p53 activates the expression of Δ133p53/Δ113p53 while Δ133p53/Δ113p53 speci...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Shi, Hui, Tao, Ting, Huang, Delai, Ou, Zhao, Chen, Jun, Peng, Jinrong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333405/
https://ncbi.nlm.nih.gov/pubmed/25550427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1359
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