Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase

Human RAD51 protein catalyzes DNA pairing and strand exchange reactions that are central to homologous recombination and homology-directed DNA repair. Successful recombination/repair requires the formation of a presynaptic filament of RAD51 on ssDNA. Mutations in BRCA2 and other proteins that contro...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Chen, Jianhong, Morrical, Milagros D., Donigan, Katherine A., Weidhaas, Joanne B., Sweasy, Joann B., Averill, April M., Tomczak, Jennifer A., Morrical, Scott W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333388/
https://ncbi.nlm.nih.gov/pubmed/25539919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1337
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