eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor cells

Translation initiation factor eIF4E mediates normal cell proliferation, yet induces tumorigenesis when overexpressed. The mechanisms by which eIF4E directs such distinct biological outputs remains unknown. We found that mouse mammary morphogenesis during pregnancy and lactation is accompanied by inc...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Avdulov, Svetlana, Herrera, Jeremy, Smith, Karen, Peterson, Mark, Gomez-Garcia, Jose R., Beadnell, Thomas C., Schwertfeger, Kathryn L., Benyumov, Alexey O., Manivel, J. Carlos, Li, Shunan, Bielinsky, Anja-Katrin, Yee, Douglas, Bitterman, Peter B., Polunovsky, Vitaly A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333007/
https://ncbi.nlm.nih.gov/pubmed/25524901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2571
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