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Age-specific functional epigenetic changes in p21 and p16 in injury-activated satellite cells
The regenerative capacity of muscle dramatically decreases with age because old muscle stem cells fail to proliferate in response to tissue damage. Here we uncover key age-specific differences underlying this proliferative decline: namely, the genetic loci of CDK inhibitors (CDKI) p21 and p16 are mo...
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| Publicado no: | Stem Cells |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4333004/ https://ncbi.nlm.nih.gov/pubmed/25447026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1908 |
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