Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

INTRODUCTION: Tocilizumab (TCZ), an anti-interleukin-6 receptor antibody, is clinically effective against rheumatoid arthritis (RA), and several reports have indicated how TCZ influences a number of mechanisms underlying RA pathogenesis. However, it is still unclear whether TCZ affects inflammatory...

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Publicat a:Arthritis Res Ther
Autors principals: Kikuchi, Jun, Hashizume, Misato, Kaneko, Yuko, Yoshimoto, Keiko, Nishina, Naoshi, Takeuchi, Tsutomu
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332922/
https://ncbi.nlm.nih.gov/pubmed/25604867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0526-4
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