Antigen Targeting to Dendritic Cells Allows the Identification of a CD4 T-Cell Epitope within an Immunodominant Trypanosoma cruzi Antigen

Targeting antigens to dendritic cells (DCs) by using hybrid monoclonal antibodies (mAbs) directed against DC receptors is known to improve activation and support long-lasting T cell responses. In the present work, we used the mAb αDEC205 fused to the Trypanosoma cruzi amastigote surface protein 2 (A...

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Bibliographic Details
Published in:PLoS One
Main Authors: Rampazo, Eline V., Amorim, Kelly N. S., Yamamoto, Marcio M., Panatieri, Raquel Hoffmann, Rodrigues, Mauricio M., Boscardin, Silvia B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332658/
https://ncbi.nlm.nih.gov/pubmed/25679777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117778
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