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Cycloheximide and Acetoxycycloheximide: Inhibition of Tyrosine Hydroxylase Activity and Amnestic Effects

Mice and rats trained after treatment with cycloheximide or acetoxycycloheximide in a conditioned avoidance response develop an amnesia of their training experience. This amnesia has been attributed to the profound inhibition of protein synthesis caused by the two antibiotics. Evidence is presented...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Flexner, Louis B., Serota, Roger G., Goodman, Richard H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1973
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433257/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4405624/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.2.354
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