F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

Mesenchymal cells such as fibroblasts are weakly polarized and reorient directionality by a lamellipodial branching mechanism that is stabilized by phosphoinositide 3-kinase (PI3K) signaling. However, the mechanisms by which new lamellipodia are initiated and directed are unknown. Using total intern...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Johnson, Heath E., King, Samantha J., Asokan, Sreeja B., Rotty, Jeremy D., Bear, James E., Haugh, Jason M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332254/
https://ncbi.nlm.nih.gov/pubmed/25666809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201406102
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