Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability

Plk4 (Polo-like kinase 4) and its binding partner Asterless (Asl) are essential, conserved centriole assembly factors that induce centriole amplification when overexpressed. Previous studies found that Asl acts as a scaffolding protein; its N terminus binds Plk4’s tandem Polo box cassette (PB1-PB2)...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Klebba, Joseph E., Galletta, Brian J., Nye, Jonathan, Plevock, Karen M., Buster, Daniel W., Hollingsworth, Natalie A., Slep, Kevin C., Rusan, Nasser M., Rogers, Gregory C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332252/
https://ncbi.nlm.nih.gov/pubmed/25688134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201410105
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