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Mutagenic DNA Polymerase in Human Leukemic Cells

Evidence is presented that DNA polymerases from human leukemic cells are mutagenic. Nucleic acid-free extracts of acute lymphoblastic leukemic cells polymerized about 10-times more dCTP using poly(dA-dT)·poly(dA-dT) as a template than did extracts from normal lymphocytes. Mutagenic DNA polymerases c...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Springgate, Clark F., Loeb, Lawrence A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1973
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433224/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4346035/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.1.245
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