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Induction of Cytolysis of Cultured Lymphoma Cells by Adenosine 3′:5′-Cyclic Monophosphate and the Isolation of Resistant Variants

Cultured mouse lymphosarcoma cells are killed on exposure to 0.1 mM N(6),O(2′)-dibutyryl-adenosine 3′:5′-cyclic monophosphate. A population of cells resistant to the killing effect of dibutyryl cyclic AMP at concentrations as high as 1 mM was selected. The growth characteristics of the resistant cel...

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Autors principals: Daniel, Violet, Litwack, Gerald, Tomkins, Gordon M.
Format: Artigo
Idioma:Inglês
Publicat: 1973
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC433187/
https://ncbi.nlm.nih.gov/pubmed/4346041
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