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Inhibition of Reticulocyte Peptide-Chain Initiation by Pactamycin: Accumulation of Inactive Ribosomal Initiation Complexes

Pactamycin does not inhibit the overall initiation factor- and GTP-dependent binding of [(35)S]Met-tRNA(f) to rabbit reticulocyte ribosomes but does prevent the formation of Met-puromycin, provided that the antibiotic is present during the course of the binding reaction. These data indicate that pac...

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Detalhes bibliográficos
Main Authors: Kappen, Lizzy S., Suzuki, Hideo, Goldberg, Irving H.
Formato: Artigo
Idioma:Inglês
Publicado em: 1973
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC433175/
https://ncbi.nlm.nih.gov/pubmed/4509656
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