Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy

X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by the accumulation of very long chain fatty acids (VLCFAs) due to a loss of function of the peroxisomal transporter ABCD1. Here, using in vivo and in vitro models, we demonstrate that autophagic flux was impaired d...

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Publicat a:Acta Neuropathol
Autors principals: Launay, Nathalie, Aguado, Carmen, Fourcade, Stéphane, Ruiz, Montserrat, Grau, Laia, Riera, Jordi, Guilera, Cristina, Giròs, Marisa, Ferrer, Isidre, Knecht, Erwin, Pujol, Aurora
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2014
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331612/
https://ncbi.nlm.nih.gov/pubmed/25549970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1378-8
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