Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2

PURPOSE: The growth and survival of neurofibromatosis type 2 (NF2)–deficient cells are enhanced by the activation of multiple signaling pathways including ErbBs/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The chaperone protein HSP90 is essential for the stabilization of these signaling molecules....

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Pubblicato in:Clin Cancer Res
Autori principali: Tanaka, Karo, Eskin, Ascia, Chareyre, Fabrice, Jessen, Walter J., Manent, Jan, Niwa-Kawakita, Michiko, Chen, Ruihong, White, Cory H., Vitte, Jeremie, Jaffer, Zahara M., Nelson, Stanley F., Rubenstein, Allan E., Giovannini, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331126/
https://ncbi.nlm.nih.gov/pubmed/23714726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3167
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