mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma

BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant genetic disorder, resulting in a variety of neural tumors, with bilateral vestibular schwannomas as the most frequent manifestation. Recently, merlin, the NF2 tumor suppressor, has been identified as a novel negative regulator o...

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Bibliographic Details
Main Authors: Giovannini, Marco, Bonne, Nicolas-Xavier, Vitte, Jeremie, Chareyre, Fabrice, Tanaka, Karo, Adams, Rocky, Fisher, Laurel M., Valeyrie-Allanore, Laurence, Wolkenstein, Pierre, Goutagny, Stephane, Kalamarides, Michel
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956353/
https://ncbi.nlm.nih.gov/pubmed/24414536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not242
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