Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers

PR-SET7-mediated histone 4 lysine 20 methylation has been implicated in mitotic condensation, DNA damage response and replication licensing. Here, we show that PR-SET7 function in the liver is pivotal for maintaining genome integrity. Hepatocyte-specific deletion of PR-SET7 in mouse embryos resulted...

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Библиографические подробности
Опубликовано в: :EMBO J
Главные авторы: Nikolaou, Kostas C, Moulos, Panagiotis, Chalepakis, George, Hatzis, Pantelis, Oda, Hisanobu, Reinberg, Danny, Talianidis, Iannis
Формат: Artigo
Язык:Inglês
Опубликовано: BlackWell Publishing Ltd 2015
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330999/
https://ncbi.nlm.nih.gov/pubmed/25515659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489279
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