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Schizophrenia Risk Variation in the NRG1 gene Exerts Effects on NRG1-IV Splicing During Fetal and Early Postnatal Human Neocortical Development

OBJECTIVE: Neuregulin 1 (NRG1) is a multifunctional neurotrophin and a critical mediator of neurodevelopment and risk for schizophrenia. NRG1 undergoes extensive alternative splicing, and association of brain NRG1-IV isoform expression with the schizophrenia-risk polymorphism, rs6994992, is a potent...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Psychiatry
Prif Awduron: Paterson, Clare, Wang, Yanhong, Kleinman, Joel E., Law, Amanda J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330971/
https://ncbi.nlm.nih.gov/pubmed/24935406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2014.13111518
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