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Structures and characterization of digoxin- and bufalin-bound Na(+),K(+)-ATPase compared with the ouabain-bound complex
Cardiotonic steroids (CTSs) are specific and potent inhibitors of the Na(+),K(+)-ATPase, with highest affinity to the phosphoenzyme (E2P) forms. CTSs are comprised of a steroid core, which can be glycosylated, and a varying number of substituents, including a five- or six-membered lactone. These fun...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4330780/ https://ncbi.nlm.nih.gov/pubmed/25624492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422997112 |
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