GPR17 gene disruption does not alter food intake or glucose homeostasis in mice

G protein-coupled receptor 17 (GPR17) was recently reported to be a Foxo1 target in agouti-related peptide (AGRP) neurons. Intracerebroventricular injection of GPR17 agonists induced food intake, whereas administration of an antagonist to the receptor reduced feeding. These data lead to the conclusi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mastaitis, Jason, Min, Soo, Elvert, Ralf, Kannt, Aimo, Xin, Yurong, Ochoa, Francisca, Gale, Nicholas W., Valenzuela, David M., Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330737/
https://ncbi.nlm.nih.gov/pubmed/25624481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424968112
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