PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission

Leukocyte common antigen-related receptor protein tyrosine phosphatases—comprising LAR, PTPδ, and PTPσ—are synaptic adhesion molecules that organize synapse development. Here, we identify glypican 4 (GPC-4) as a ligand for PTPσ. GPC-4 showed strong (nanomolar) affinity and heparan sulfate (HS)-depen...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ko, Ji Seung, Pramanik, Gopal, Um, Ji Won, Shim, Ji Seon, Lee, Dongmin, Kim, Kee Hun, Chung, Gug-Young, Condomitti, Giuseppe, Kim, Ho Min, Kim, Hyun, de Wit, Joris, Park, Kang-Sik, Tabuchi, Katsuhiko, Ko, Jaewon
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330736/
https://ncbi.nlm.nih.gov/pubmed/25624497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410138112
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