Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury

Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner pathogenic or pro-regenerative f...

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Published in:Sci Rep
Main Authors: Scheiermann, Patrick, Bachmann, Malte, Härdle, Lorena, Pleli, Thomas, Piiper, Albrecht, Zwissler, Bernhard, Pfeilschifter, Josef, Mühl, Heiko
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330543/
https://ncbi.nlm.nih.gov/pubmed/25687687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08521
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