Absence of Intracellular Ion Channels TPC1 and TPC2 Leads to Mature-Onset Obesity in Male Mice, Due to Impaired Lipid Availability for Thermogenesis in Brown Adipose Tissue

Intracellular calcium-permeable channels have been implicated in thermogenic function of murine brown and brite/beige adipocytes, respectively transient receptor potential melastin-8 and transient receptor potential vanilloid-4. Because the endo-lysosomal two-pore channels (TPCs) have also been ascr...

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Опубликовано в: :Endocrinology
Главные авторы: Lear, Pamela V., González-Touceda, David, Porteiro Couto, Begoña, Viaño, Patricia, Guymer, Vanessa, Remzova, Elena, Tunn, Ruth, Chalasani, Annapurna, García-Caballero, Tomás, Hargreaves, Iain P., Tynan, Patricia W., Christian, Helen C., Nogueiras, Rubén, Parrington, John, Diéguez, Carlos
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2015
Предметы:
Energy Balance-Obesity
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330317/
https://ncbi.nlm.nih.gov/pubmed/25545384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1766
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