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Heavier Ions with a Different Linear Energy Transfer Spectrum Kill More Cells Due to Similar Interference with the Ku-Dependent DNA Repair Pathway

Ionizing radiation kills cells mainly due to the generation of DNA double-strand breaks (DSBs). High-linear energy transfer (LET) ionizing radiation induces more cell death and generates a higher relative biological effect (RBE) than low-LET ionizing radiation (such as X or γ ray). Although it is kn...

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Detalles Bibliográficos
Publicado en:Radiat Res
Main Authors: Wang, Hongyan, Wang, Ya
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329976/
https://ncbi.nlm.nih.gov/pubmed/25229976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR13857.1
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