Comparison of Standardized Uptake Values with Volume of Distribution for Quantitation of [(11)C]PBR28 Brain Uptake

INTRODUCTION: [(11)C]PBR28 is a high-affinity ligand for the Translocator Protein 18kDa (TSPO), which is considered to be a marker for microglial activation. Volume of distribution (V(T)) estimated with an arterial plasma input function is the gold standard for quantitation of [(11)C]PBR28 binding....

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Published in:Nucl Med Biol
Main Authors: Yoder, Karmen K., Territo, Paul R., Hutchins, Gary D., Hannestad, Jonas, Morris, Evan D., Gallezot, Jean-Dominique, Normandin, Marc D., Cosgrove, Kelly P.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329090/
https://ncbi.nlm.nih.gov/pubmed/25487553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.11.003
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