Effects and cost-effectiveness of pharmacogenetic screening for CYP2D6 among older adults starting therapy with nortriptyline or venlafaxine: study protocol for a pragmatic randomized controlled trial (CYSCEtrial)

BACKGROUND: Nortriptyline and venlafaxine are commonly used antidepressants for treatment of depression in older patients. Both drugs are metabolized by the polymorphic cytochrome P450-2D6 (CYP2D6) enzyme and guidelines for dose adaptations based on the CYP2D6 genotype have been developed. The CYP2D...

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Bibliographische Detailangaben
Veröffentlicht in:Trials
Hauptverfasser: Berm, Elizabeth JJ, Hak, Eelko, Postma, Maarten, Boshuisen, Marjolein, Breuning, Laura, Brouwers, Jacobus RBJ, Dhondt, Ton, Jansen, Paul AF, Kok, Rob M, Maring, Jan G, van Marum, Rob, Mulder, Hans, Voshaar, Richard C Oude, Risselada, Arne J, Venema, Harry, Vleugel, Liesbeth, Wilffert, Bob
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4328880/
https://ncbi.nlm.nih.gov/pubmed/25636328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0561-0
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