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IFNG rs1861494 Polymorphism is Associated with IBD Disease Severity and Functional Changes in both IFNG Methylation and Protein Secretion
BACKGROUND: Mucosal expression of IFN-γ plays a pivotal role in IBD pathogenesis and IBD-risk regions flank IFNG. The conserved IFNG rs1861494 T/C, introduces a new CpG methylation site, and is associated with disease severity and lack of therapeutic response in other infectious and immune mediated...
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| 出版年: | Inflamm Bowel Dis |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4327845/ https://ncbi.nlm.nih.gov/pubmed/25171510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000172 |
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