Emergence of a STAT3 mutated NK clone in LGL leukemia

Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK b...

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Bibliographische Detailangaben
Veröffentlicht in:Leuk Res Rep
Hauptverfasser: Yan, Yiyi, Olson, Thomas L., Nyland, Susan B., Feith, David J., Loughran, Thomas P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327758/
https://ncbi.nlm.nih.gov/pubmed/25709890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2014.12.001
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