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Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues

A series of synthetic analogues of 1-d-(2-amino-2-deoxy-α-d-glucopyranosyl)-myo-inositol 1-(1,2-di-O-hexadecanoyl-sn-glycerol 3-phosphate), consisting of 7 variants of either the d-myo-inositol, d-GlcpN or the phospholipid components, were prepared and tested as substrates and inhibitors of GlcNAc-P...

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Dettagli Bibliografici
Pubblicato in:Org Biomol Chem
Autori principali: Capes, Amy S., Crossman, Arthur, Urbaniak, Michael D., Gilbert, Sophie H., Ferguson, Michael A. J., Gilbert, Ian H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326964/
https://ncbi.nlm.nih.gov/pubmed/24519084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42164c
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