Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

The zinc-metalloenzyme GlcNAc-PI de-N-acetylase is essential for the biosynthesis of mature GPI anchors and has been genetically validated in the bloodstream form of Trypanosoma brucei, which causes African sleeping sickness. We screened a focused library of zinc-binding fragments and identified sal...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Urbaniak, Michael D., Capes, Amy S., Crossman, Arthur, O’Neill, Sandra, Thompson, Stephen, Gilbert, Ian H., Ferguson, Michael A.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991331/
https://ncbi.nlm.nih.gov/pubmed/24589444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2013.12.016
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados