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Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase

The zinc-metalloenzyme GlcNAc-PI de-N-acetylase is essential for the biosynthesis of mature GPI anchors and has been genetically validated in the bloodstream form of Trypanosoma brucei, which causes African sleeping sickness. We screened a focused library of zinc-binding fragments and identified sal...

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מידע ביבליוגרפי
Main Authors: Urbaniak, Michael D., Capes, Amy S., Crossman, Arthur, O’Neill, Sandra, Thompson, Stephen, Gilbert, Ian H., Ferguson, Michael A.J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991331/
https://ncbi.nlm.nih.gov/pubmed/24589444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2013.12.016
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