Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine

An abnormal accumulation of cholesterol oxidation products in the brain of patients with Alzheimer’s disease (AD) would further link an impaired cholesterol metabolism in the pathogenesis of the disease. The first evidence stemming from the content of oxysterols in autopsy samples from AD and normal...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Gamba, Paola, Guglielmotto, Michela, Testa, Gabriella, Monteleone, Debora, Zerbinati, Chiara, Gargiulo, Simona, Biasi, Fiorella, Iuliano, Luigi, Giaccone, Giorgio, Mauro, Alessandro, Poli, Giuseppe, Tamagno, Elena, Leonarduzzi, Gabriella
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326893/
https://ncbi.nlm.nih.gov/pubmed/24612036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12206
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