Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine

An abnormal accumulation of cholesterol oxidation products in the brain of patients with Alzheimer’s disease (AD) would further link an impaired cholesterol metabolism in the pathogenesis of the disease. The first evidence stemming from the content of oxysterols in autopsy samples from AD and normal...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Gamba, Paola, Guglielmotto, Michela, Testa, Gabriella, Monteleone, Debora, Zerbinati, Chiara, Gargiulo, Simona, Biasi, Fiorella, Iuliano, Luigi, Giaccone, Giorgio, Mauro, Alessandro, Poli, Giuseppe, Tamagno, Elena, Leonarduzzi, Gabriella
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326893/
https://ncbi.nlm.nih.gov/pubmed/24612036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12206
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