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Interactions with the Bifunctional Interface of the Transcriptional Coactivator DCoH1 Are Kinetically Regulated

Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved enzyme that evolved a second, unrelated function in mammals, as a transcriptional coactivator. As a coactivator, PCD is known as DCoH or dimerization cofactor of the transcription factor HNF-1. These two activities are associated with a...

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Publicat a:J Biol Chem
Autors principals: Wang, Dongli, Coco, Matthew W., Rose, Robert B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326839/
https://ncbi.nlm.nih.gov/pubmed/25538247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616870
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