High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue.

DCoH, the dimerization cofactor of hepatocyte nuclear factor 1 (HNF-1), functions as both a transcriptional coactivator and a pterin dehydratase. To probe the relationship between these two functions, the X-ray crystal structures of the free enzyme and its complex with the product analogue 7,8-dihyd...

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Bibliographic Details
Main Authors: Cronk, J. D., Endrizzi, J. A., Alber, T.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143270/
https://ncbi.nlm.nih.gov/pubmed/8897596
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