Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach

Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a disorder characterized by coronary heart disease (CHD) at young age. We aimed to apply an extreme sampling method to enhance the statistical power to identify novel genetic risk variants for CHD...

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Publicado no:Eur J Hum Genet
Main Authors: Versmissen, Jorie, Oosterveer, Daniëlla M, Yazdanpanah, Mojgan, Dehghan, Abbas, Hólm, Hilma, Erdman, Jeanette, Aulchenko, Yurii S, Thorleifsson, Gudmar, Schunkert, Heribert, Huijgen, Roeland, Vongpromek, Ranitha, Uitterlinden, André G, Defesche, Joep C, van Duijn, Cornelia M, Mulder, Monique, Dadd, Tony, Karlsson, Hróbjartur D, Ordovas, Jose, Kindt, Iris, Jarman, Amelia, Hofman, Albert, van Vark-van der Zee, Leonie, Blommesteijn-Touw, Adriana C, Kwekkeboom, Jaap, Liem, Anho H, van der Ouderaa, Frans J, Calandra, Sebastiano, Bertolini, Stefano, Averna, Maurizio, Langslet, Gisle, Ose, Leiv, Ros, Emilio, Almagro, Fátima, de Leeuw, Peter W, Civeira, Fernando, Masana, Luis, Pintó, Xavier, Simoons, Maarten L, Schinkel, Arend FL, Green, Martin R, Zwinderman, Aeilko H, Johnson, Keith J, Schaefer, Arne, Neil, Andrew, Witteman, Jacqueline CM, Humphries, Steve E, Kastelein, John JP, Sijbrands, Eric JG
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326701/
https://ncbi.nlm.nih.gov/pubmed/24916650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2014.101
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