Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogra...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Carroll, Patrick A., Diolaiti, Daniel, McFerrin, Lisa, Gu, Haiwei, Djukovic, Danijel, Du, Jianhai, Cheng, Pei Feng, Anderson, Sarah, Ulrich, Michelle, Hurley, James B., Raftery, Daniel, Ayer, Donald E., Eisenman, Robert N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326605/
https://ncbi.nlm.nih.gov/pubmed/25640402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.024
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