Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogra...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Cell
Hlavní autoři: Carroll, Patrick A., Diolaiti, Daniel, McFerrin, Lisa, Gu, Haiwei, Djukovic, Danijel, Du, Jianhai, Cheng, Pei Feng, Anderson, Sarah, Ulrich, Michelle, Hurley, James B., Raftery, Daniel, Ayer, Donald E., Eisenman, Robert N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326605/
https://ncbi.nlm.nih.gov/pubmed/25640402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.024
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky