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Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis
Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogra...
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Pubblicato in: | Cancer Cell |
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Autori principali: | , , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
2015
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4326605/ https://ncbi.nlm.nih.gov/pubmed/25640402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.11.024 |
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