Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors

Most cancer therapies involve a component of treatment which inflicts DNA damage in tumor cells, such as double-strand breaks (DSBs), which are considered the most serious threat to genomic integrity. Complex systems have evolved to repair these lesions, and successful DSB repair is essential for tu...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Goglia, Alexander G., Delsite, Robert, Luz, Antonio N., Shahbazian, David, Salem, Ahmed F., Sundaram, Ranjini K., Chiaravalli, Jeanne, Hendrikx, Petrus J., Wilshire, Jennifer A., Jasin, Maria, Kluger, Harriet, Glickman, J. Fraser, Powell, Simon N., Bindra, Ranjit S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326563/
https://ncbi.nlm.nih.gov/pubmed/25512618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0765
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