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The protective effect of growth hormone on Cu/Zn superoxide dismutase-mutant motor neurons

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. The gene encoding Cu/Zn superoxide dismutase (SOD1) is responsible for 20% of familial ALS cases. Growth hormone (GH) concentrations are low in the cerebrospinal fluid of patients with ALS; h...

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Publicat a:BMC Neurosci
Autors principals: Chung, Jin-Young, Kim, Hyun-Jung, Kim, Manho
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326297/
https://ncbi.nlm.nih.gov/pubmed/25655275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-015-0140-z
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