IFNL4 and IFNL3 Associated Polymorphisms Strongly Influence the Spontaneous IFN-Alpha Receptor-1 Expression in HCV-Infected Patients

Single-nucleotide polymorphism in IFNL3 gene (rs12979860) predicts spontaneous and therapy-induced HCV clearance. In a previous study from our group PBMC from patients with favourable rs12979860 genotype showed higher levels of IFNAR-1 mRNA. Recently, a dinucleotide polymorphism, ss469415590 (TT or...

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Publicat a:PLoS One
Autors principals: Bordi, Licia, Caglioti, Claudia, Garbuglia, Anna Rosa, Lapa, Daniele, Castilletti, Concetta, Taibi, Chiara, Capobianchi, Maria Rosaria, Lalle, Eleonora
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326132/
https://ncbi.nlm.nih.gov/pubmed/25675103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117397
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