Antagonistic Antiviral Activity between IFN-Lambda and IFN-Alpha against Lethal Crimean-Congo Hemorrhagic Fever Virus In Vitro

BACKGROUND AND AIMS: Crimean Congo Hemorrhagic fever virus (CCHFV) is the causative agent of Crimean-Congo hemorrhagic fever, a severe disease with a mortality rate of around 30% in humans. Previous studies demonstrate that pre-treatment with type I IFNs have an antiviral effect against CCHFV, while...

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Udgivet i:PLoS One
Main Authors: Bordi, Licia, Lalle, Eleonora, Caglioti, Claudia, Travaglini, Damiano, Lapa, Daniele, Marsella, Patrizia, Quartu, Serena, Kis, Zoltan, Arien, Kevin K., Huemer, Hartwig P., Meschi, Silvia, Ippolito, Giuseppe, Di Caro, Antonino, Capobianchi, Maria R., Castilletti, Concetta
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333211/
https://ncbi.nlm.nih.gov/pubmed/25693189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116816
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