Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways

Intrastriatal injection of recombinant adeno-associated viral vector serotype 2/1 (rAAV2/1) to overexpress the neurotrophic factor pleiotrophin (PTN) provides neuroprotection for tyrosine hydroxylase immunoreactive (THir) neurons in the substantia nigra pars compacta (SNpc), increases THir neurite d...

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Pubblicato in:Gene Ther
Autori principali: Gombash, SE, Manfredsson, FP, Mandel, RJ, Collier, TJ, Fischer, DL, Kemp, CJ, Kuhn, NM, Wohlgenant, SL, Fleming, SM, Sortwell, CE
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326069/
https://ncbi.nlm.nih.gov/pubmed/24807806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.42
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