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The Strength of Synergistic Interaction between Posaconazole and Caspofungin Depends on the Underlying Azole Resistance Mechanism of Aspergillus fumigatus

The majority of azole resistance mechanisms in Aspergillus fumigatus correspond to mutations in the cyp51A gene. As azoles are less effective against infections caused by multiply azole-resistant A. fumigatus isolates, new therapeutic options are warranted for treating these infections. We therefore...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Mavridou, Eleftheria, Meletiadis, Joseph, Rijs, Antony, Mouton, Johan W., Verweij, Paul E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325813/
https://ncbi.nlm.nih.gov/pubmed/25583716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04469-14
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