Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine

[Image: see text] 5-Hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) form during active demethylation of 5-methylcytosine (5mC) and are implicated in epigenetic regulation of the genome. They are differentially processed by thymine DNA glycosylase (TDG), an enzyme...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Szulik, Marta W., Pallan, Pradeep S., Nocek, Boguslaw, Voehler, Markus, Banerjee, Surajit, Brooks, Sonja, Joachimiak, Andrzej, Egli, Martin, Eichman, Brandt F., Stone, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325598/
https://ncbi.nlm.nih.gov/pubmed/25632825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501534x
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