Inter-species pathway perturbation prediction via data-driven detection of functional homology

Motivation: Experiments in animal models are often conducted to infer how humans will respond to stimuli by assuming that the same biological pathways will be affected in both organisms. The limitations of this assumption were tested in the IMPROVER Species Translation Challenge, where 52 stimuli we...

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Опубликовано в: :Bioinformatics
Главные авторы: Hafemeister, Christoph, Romero, Roberto, Bilal, Erhan, Meyer, Pablo, Norel, Raquel, Rhrissorrakrai, Kahn, Bonneau, Richard, Tarca, Adi L.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2015
Предметы:
Improver Challenge Special Issue; Species Translation Challenge
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325539/
https://ncbi.nlm.nih.gov/pubmed/25150249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu570
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