Inter-species pathway perturbation prediction via data-driven detection of functional homology

Motivation: Experiments in animal models are often conducted to infer how humans will respond to stimuli by assuming that the same biological pathways will be affected in both organisms. The limitations of this assumption were tested in the IMPROVER Species Translation Challenge, where 52 stimuli we...

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Bibliographic Details
Published in:Bioinformatics
Main Authors: Hafemeister, Christoph, Romero, Roberto, Bilal, Erhan, Meyer, Pablo, Norel, Raquel, Rhrissorrakrai, Kahn, Bonneau, Richard, Tarca, Adi L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Improver Challenge Special Issue; Species Translation Challenge
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325539/
https://ncbi.nlm.nih.gov/pubmed/25150249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu570
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